Social determinants of health (SDoH) are nonmedical factors like economic stability, neighborhood and physical environment, education, food, community and social context, and the healthcare system, which have significant effects on health outcomes. We are involved in a number of projects that investigate the influence of SDoH on individuals’ ability to obtain services, prevent unnecessary hospitalizations, and age in place. We have also established strong research partnerships with community organizations, medical centers, and health care clinics that provide assistance to vulnerable populations (e.g., older individuals with functional and financial need, those living in more rural communities). Findings from this work have strong implications for preventive health initiatives to reduce the risks associated with having unmet SDoH.